Endocrine Abstracts

As known, the number of obese people in the world exceeds 50% of the total population. Тo search the causes of obesity development many researchers pay attention to metabolites of intestinal microflora among which the main ones are short–chain fatty acids (SCFA): acetate (C2), propionate(C3), butyrate(C4). Hormones of food behavior produced by visceral adipose tissue (leptin) and cells of the gastrointestinal tract (ghrelin) also play an important role in the devel...

The key factor in the pathogenesis of both T2D and NAFLD is insulin resistance, which causes the lipids accumulation in hepatocytes and an increase of the lipid peroxidation, the production of reactive oxygen species and the development of inflammation. It has been shown that the main metabolic products of the saccharolytic microflora-short-chain fatty acids (SCFA), such as acetic (Ac), propionic (Pr) and butyric (Bu), can have an anti-inflammatory effect through their suppres...

Background: Type 2 diabetes (T2D) is a progressive disease. The gut microbiota has recently been identified as a new potential diabetes risk factor. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve T2D.Aims: To examine the effectiveness of glucagon-like peptide (GLP)-1 receptor agonist treatment on SCFAs, carbohydrate and lipid metabolism in patients w...

Background: Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material. SCFAs play an important role in health and disease. They may reduce the risk of inflammatory diseases, type 2 diabetes, obesity, heart disease and other conditions.Aims: to examine the effectivenessof glucagon-like peptide (GLP)-1 receptor agonist and prebiotic treatment on SCFAs, carbohydrate metabolism in pa...

AimTo assess the effect of Zakofalk in complex therapy in patients with type 2 diabetes and obesity.Materials and methodsWe examined 68 patients with type 2 diabetes and 28 with obesity (body mass index over 30 kg/m2). The control group consisted of 20 people. The groups were comparable in terms of age, sex, and antihyperglycemic therapy. In addition to a thorough clinical examination of all study ...